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论文证实,武汉肺炎病毒与 SARS 病毒非常相似

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发表于 2020-1-31 11:04:41 | 显示全部楼层 |阅读模式
当初把武汉肺炎病毒称为 SARS 的人并非“造谣”。



Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

http://engine.scichina.com/publi ... 637-5?slug=fulltext

......

When compared to the genomes of SARS-CoV and MERS-CoV, the WH-human_1 genome that was used as representative of the Wuhan CoV, shared a better sequence homology toward the genomes of SARS-CoV than that of MERS-CoV (Figure S1B in Supporting Information).

......

The Wuhan CoV cluster is situated with the groups of SARS/SARS-like coronaviruses, with bat coronavirus HKU9-1 as the immediate outgroup. Its inner joint neighbors are SARS or SARS-like coronaviruses, including the human-infecting ones (Figure 1A, marked with red star).



......

The model of the Wuhan CoV S-protein (brown ribbon) is superimposed with the structural template of the SARS CoV S-protein (light blue ribbon).

......

Based on the computer-guided homology modeling method, the structural model of the Wuhan CoV S-protein was constructed by Swiss-model using the crystal structure of SARS coronavirus S-protein (PDB accession: 6ACD) as a template (Schwede et al., 2003). Note the amino acid sequence identity between the Wuhan-CoV and SARS-CoV S-proteins is 76.47%.

......

So to our surprise, despite replacing four out of five important interface amino acid residues, the Wuhan CoV S-protein was found to have a significant binding affinity to human ACE2. Looking more closely, the replacing residues at positions 442, 472, 479, and 487 in the Wuhan CoV S-protein did not alter the structural confirmation. The Wuhan CoV S-protein and SARS-CoV S-protein shared an almost identical 3-D structure in the RBD domain, thus maintaining similar van der Waals and electrostatic properties in the interaction interface.

In summary, our analysis showed that the Wuhan CoV shared with the SARS/SARS-like coronaviruses a common ancestor that resembles the bat coronavirus HKU9-1. Our work points to the important discovery that the RBD domain of the Wuhan CoV S-protein supports strong interaction with human ACE2 molecules despite its sequence diversity with SARS-CoV S-protein. Thus the Wuhan CoV poses a significant public health risk for human transmission via the S-protein–ACE2 binding pathway.




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 楼主| 发表于 2020-1-31 11:07:22 | 显示全部楼层
武汉肺炎的惊天内幕正在浮现

作者:夏小强

https://www.aboluowang.com/2020/0130/1402833.html

1月28日,在美国卫生部门当天举行的新闻发布会上,美国卫生部长亚历克斯·阿扎尔(Alex Azar)表示,美国继续提出派遣美国疾病控制与预防中心(CDC)官员前往中国帮助应对武汉肺炎疫情,但被中共政府再次拒绝。

在重大的天灾发生后,中共拒绝国际援助是一种常态,在历史上有过多次。但是,这一次拒绝拥有世界顶级专业技术的美国团队进入中国,和以往的原因理由都不相同,很大可能,是中共要掩盖这次武汉肺炎病毒来源的真相。

多种迹象显示,造成这次武汉肺炎的惊人内幕正在浮现。

一篇论文透出病毒来源

2020年1月21日,中国科学院上海巴斯德研究所郝沛研究员、军事医学研究院国家应急防控药物工程技术研究中心钟武研究员和中科院分子植物卓越中心合成生物学重点实验室李轩研究员合作,在《SCIENCE CHINA Life Sciences》(《中国科学:生命科学》英文版),在线发表了题为“Evolution of the novel coronavirus from the ongoing Wuhan outbreakand modeling of its spike protein for risk of human transmission”的论文。

该论文分析阐述了引起近期武汉地区肺炎疫情爆发的新型冠状病毒的进化来源,及与导致2002年广东“非典”疫情的SARS冠状病毒、“中东呼吸综合征”MERS冠状病毒的遗传进化关系,并通过对武汉的新型冠状病毒spike-蛋白的结构模拟计算,揭示了武汉新型冠状病毒spike-与人ACE2蛋白作用并介导传染人的分子作用通路。

该成果评估了武汉新型冠状病毒的潜在人间传染力,为尽快确认传染源和传播途径、制定高效的防控策略提供了科学理论依据。

这篇论文最重要的结论是,武汉新型冠状病毒虽然换掉了4个关键蛋白,但是与人ACE2的亲和力还是很强。研究人员在吃惊之余,又仔细地比较了SARS的S-蛋白与武汉新型冠状病毒的S-蛋白结构,结果发现,虽然替换了4个关键氨基酸,但是结构并没有发生变化,二者RBD结构域的3D结构几乎相同。

难怪新型肺炎病毒和SARS那么像。

这个研究说明武汉新型冠状病毒应该是通过S-蛋白与人ACE2相互作用,来感染人的呼吸道上皮细胞。而且,这个结果也暗示,武汉新型冠状病毒具有很强的对人感染能力。

这个新型冠状病毒换掉了4个关键蛋白!这是与SARS的最大不同!

病毒的变异只有两种渠道,第一,自然变异;第二,人工干预。如果是自然变异,这种病毒精确换掉4个蛋白至少要经历1万次以上变异才能实现。机遇极小。假如不是自然变异,那就只有一种可能——人工干预基因改变!那么作者会是谁呢?

这篇论文从专业角度得出的结论就是:武汉肺炎新型冠状病毒,人工干预基因改变的可能性很大。

......

病毒来源于生化武器实验?

《华盛顿时报》于1月24日报导,研究过中共生物战的前以色列军事情报官员肖汉姆(Dany Shoham)披露,武汉的P4实验室也与中共军方有关,并可能参与了中共的生物武器计划,中共的抗SARS疫苗就是在那里生产的。肖汉姆说:“这意味著SARS病毒将在那里保存和繁殖”,但是他认为SARS病毒与武汉肺炎病毒并不完全相同。

根据以上多种信息,我们或许可以做出推测或者判断:此次武汉肺炎新型冠状病毒,是在武汉P4实验室人工改变病毒基因而产生,可能是中共军方研制生化武器的一种。

那么,此病毒从实验室传出有两种可能。一种是实验人员操作不当或者没有做好防护工作不慎泄露。

另外一种可能,就是中共高层在激烈内斗中失势的一方,用超限战方式,人为地释放出病毒,制造瘟疫来对付政敌,同时也制造翻盘的机会。这种判断虽然颇有些阴谋论的味道,但是,中共的邪恶已经超出人类的任何想像,或许真实的情况,要超出阴谋论的推断百倍千倍。

据坊间传闻,中共早在12月底,已经非常清楚疫情失控,但是武汉市政府在封城前“4天”,也就是1月20号,还在全国发放“20万张”包括黄鹤楼在内30个武汉景点的免费门票!而武汉居民反馈说以前从来没有这种操作,这种反常的行为,颇有刻意扩散病毒的嫌疑。

随著事态的发展,越来越多的真相将会出现。人们将会发现,随著这次巨大灾难的降临,越来越多的那些原本相信“党和政府”的中国民众开始认识到:中共政权才是造成巨大灾难的元凶。



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匿名
匿名  发表于 2020-2-1 11:27:00
【武汉肺炎病毒从蝙蝠传给蛇,再从蛇传给人?外国学者质疑:蝙蝠是温血动物,蛇是冷血动物,人是温血动物。同一病毒为何既能寄生于温血动物,也能寄生于冷血动物?病毒的自然变异能做到这点吗?是否有人工基因编辑的可能?】

https://www.scientificamerican.c ... -outbreak-in-china/

The study of the genetic code of 2019-nCoV reveals that the new virus is most closely related to two bat SARS-like coronavirus samples from China, initially suggesting that, like SARS and MERS, the bat might also be the origin of 2019-nCoV. The authors further found that the DNA coding sequence of 2019-nCoV spike protein, which forms the “crown” of the virus particle that recognizes the receptor on a host cell, indicates that the bat virus might have mutated before infecting people.

But when the researchers performed a more detailed bioinformatics analysis of the sequence of 2019-nCoV, it suggests that this coronavirus might come from snakes.

From bats to snakes

The researchers used an analysis of the protein codes favored by the new coronavirus and compared it to the protein codes from coronaviruses found in different animal hosts, like birds, snakes, marmots, hedgehogs, manis, bats and humans. Surprisingly, they found that the protein codes in the 2019-nCoV are most similar to those used in snakes.

Snakes often hunt for bats in wild. Reports indicate that snakes were sold in the local seafood market in Wuhan, raising the possibility that the 2019-nCoV might have jumped from the host species—bats—to snakes and then to humans at the beginning of this coronavirus outbreak. However, how the virus could adapt to both the cold-blooded and warm-blooded hosts remains a mystery.

Coronavirus: Its original source is possibly ... Snakes

https://www.dailykos.com/stories ... -is-possibly-Snakes

Preliminary DNA analysis has identified snakes — the Chinese krait and the Chinese cobra — as the possible original source of the virus.

......

How the virus could jump and proliferate from warm-blooded bats to cold-blooded reptiles to warm-blooded humans remains a mystery to be solved.

This study is disputed by some other scientists, who argue that the wildlife reservoir must be bird or mammal. “They have no evidence snakes can be infected by this new coronavirus and serve as a host for it,” says Paulo Eduardo Brandao, a virologist at the University of Sao Paulo who is investigating whether coronaviruses can infect snakes at all. “There’s no consistent evidence of coronaviruses in hosts other than mammals and Aves (birds).



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发表于 2020-2-1 11:30:04 | 显示全部楼层
共匪拒绝向美国提供H7N9禽流感病毒样本(怕被美方抓到证据?怕美方研制出疫苗,使该生物武器失效?)

https://cn.nytimes.com/health/20180828/china-flu-virus-samples/


【RFA】共匪拒分享H7N9病毒样本后果严重

https://www.rfa.org/mandarin/yat ... 08282018105635.html


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发表于 2020-2-1 11:32:37 | 显示全部楼层
【武汉肺炎病毒的 Ro 值达到 4.08】

Scientists warn nCoV more infectious than SARS, but experts have doubts

(链接发不出)

The scientists, from the Chinese Academy of Sciences Institute of Automation and the University of Chinese Academy of Sciences, both in in Beijing, calculated an R0 of 4.08 for the current outbreak, meaning a person infected with 2019-nCoV could infect more than four susceptible people.

This figure is higher than the World Health Organization's estimate of 1.4 to 2.5 and a recent model that showed an R0 between 3.6 and 4

How contagious is the Wuhan Coronavirus? (Ro)

(链接发不出)

The attack rate or transmissibility (how rapidly the disease spreads) of a virus is indicated by its reproductive number (Ro, pronounced R-nought or r-zero), which represents the average number of people who will catch the disease from a single infected person.

A more recent study is indicating a Ro as high as 4.08. This value substantially exceeds WHO's estimate (made on Jan. 23) of between 1.4 and 2.5[13], and is also higher than recent estimates between 3.6 and 4.0 and between 2.24 to 3.58 [23]. Preliminary studies had estimated Ro to be between 1.5 and 3.5 [5][6][7]

Based on these numbers, on average every case of the Novel Coronavirus would create 3 to 4 new cases.


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发表于 2020-2-1 11:33:23 | 显示全部楼层
【早前评估的 Ro 值是 3.8,已经被专家称为“热核武级别”、在多年的职业生涯中从未见过。此病毒可能非自然生成?】

https://www.ntdtv.com/gb/2020/01/26/a102761208.html




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发表于 2020-2-4 11:09:44 | 显示全部楼层
本帖最后由 ddmlmg 于 2020-2-4 11:29 编辑

武汉病毒研究所的 石正丽、葛兴义 于 2015 年 11 月 9 日在 Nature Medicine 上发表的论文,承认他们人工合成了 SARS-CoV 病毒(类SARS冠状病毒),该病毒能利用 SARS 的感染机制来感染人类。

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

Published: 09 November 2015

https://www.nature.com/articles/nm.3985
Vineet D Menachery, Boyd L Yount Jr, Kari Debbink, Sudhakar Agnihothram, Lisa E Gralinski, Jessica A Plante, Rachel L Graham, Trevor Scobey, Xing-Yi Ge, Eric F Donaldson, Scott H Randell, Antonio Lanzavecchia, Wayne A Marasco, Zhengli-Li Shi & Ralph S Baric

论文作者 葛兴义、石正丽 皆来自 武汉病毒研究所:
Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

Xing-Yi Ge & Zhengli-Li Shi


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发表于 2020-2-4 11:11:36 | 显示全部楼层
论文内容发不出来,要审核。

为何英文内容总是发不出来,要审核???
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发表于 2020-2-4 11:25:45 | 显示全部楼层
wh.virus.png
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匿名
匿名  发表于 2020-2-4 19:46:15

该人造病毒被称为 SHC014-MA15,论文详细叙述了他们人工合成病毒,并先后进行 in vitro (实验皿繁殖)和 in Vivo (动物活体繁殖)的实验过程。实验非常成功,新制造的病毒繁殖和传染能力极强,并且现有一切疫苗无效,且实验老鼠症状跟现在武汉肺炎病人症状一模一样。实验结果同时证明,在老鼠体内繁殖成功的此种人造冠状病毒可高效感染人类。




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匿名
匿名  发表于 2020-2-5 05:36:27
wh.vir.jpg
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匿名  发表于 2020-2-5 06:37:00
在基因银行注册的 AVP78033.1 病毒,由南京军事医学研究所 于 2018 年提交:

https://www.ncbi.nlm.nih.gov/protein/AVP78033
envelope protein [Bat SARS-like coronavirus]
GenBank: AVP78033.1

Submitted (05-JAN-2018) Institute of Military Medicine Nanjing
Command, Nanjing, Institute of Military Medicine Nanjing Command,
Nanjing, NO. 293 East Zhongshan Road, Nanjing, JangSu 210002, China

在基因银行注册的 QHD43418.1 病毒,即武汉海鲜市场病毒:

https://www.ncbi.nlm.nih.gov/protein/QHD43418.1
envelope protein [Wuhan seafood market pneumonia virus]
GenBank: QHD43418.1

Submitted (05-JAN-2020) Shanghai Public Health Clinical Center &
School of Public Health, Fudan University, Shanghai, China

基因组比对发现,这两个病毒的78个基因组序列完全一致:

https://flutrackers.com/forum/fo ... e-protein-2019-ncov
GenBank version QHD43418.1 is the submittal number from the envelope protein from the current 2019-nCov entered January 17, 2020.

GenBank version AVP78033.1 is the submittal number from the envelope protein for Bat SARS-like coronavirus January 5, 2018

"Using the BLAST tool from US National Library of Medicine, running multigenetic genome matches on these two genetic sequences, for 78 sequences, a 100% match on the envelope protein occurs."



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匿名  发表于 2020-2-5 10:38:08
NCBI 中的另一条记录:YP_009724392.1,即武汉海鲜市场病毒,与 QHD43418.1 是同一病毒:

https://www.ncbi.nlm.nih.gov/protein/YP_009724392.1
envelope protein [Wuhan seafood market pneumonia virus]

COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to QHD43418.

运行 BLAST(Basic Local Alignment Search Tool),发现解放军研制的  AVP78033.1 病毒的包膜(envelope protein)与武汉海鲜市场病毒(YP_009724392.1,即 QHD43418)的包膜100%一致:

wh.vir.1.png

病毒包膜(Viral envelope)使病毒免受宿主(人或动物)的免疫系统攻击,并使病毒能感染宿主。 AVP78033.1 病毒的包膜与 QHD43418 病毒的包膜一致,意味着二者的感染机制相同。武汉海鲜市场病毒 QHD43418 可以感染人类,解放军研制的  AVP78033.1 病毒也可以感染人类。

【Wikipedia】 Viral envelope

https://en.wikipedia.org/wiki/Viral_envelope

Some viruses (e.g. HIV and many animal viruses) have viral envelopes covering their protective protein capsids.[1] The envelopes are typically derived from portions of the host cell membranes (phospholipids and proteins), but include some viral glycoproteins. They may help viruses avoid the host immune system. Glycoproteins on the surface of the envelope serve to identify and bind to receptor sites on the host's membrane. The viral envelope then fuses with the host's membrane, allowing the capsid and viral genome to enter and infect the host.

另一高度相似的病毒是 Bat SARS-like coronavirus RsSHC014,在基因银行注册为 AGZ48809.1,由 武汉病毒研究所 于 2013 年提交:

https://www.ncbi.nlm.nih.gov/protein/AGZ48809.1
envelope protein [Bat SARS-like coronavirus RsSHC014]
GenBank: AGZ48809.1

Submitted (08-APR-2013) Wuhan Institute of Virology, Chinese Academy of Sciences, 44 Xiao Hong Shan, Wuhan, Hubei 430071, China



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匿名
匿名  发表于 2020-2-7 08:58:19
本帖最后由 匿名 于 2020-2-7 10:29 编辑

香港也出现多处行人突然倒地的情况,主流媒体全不报道:

https://www.ptt.cc/bbs/Gossiping/M.1580514798.A.DB7.html















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发表于 2020-2-7 10:26:26 | 显示全部楼层
外国生物学家在 Nature Medicine 上发表文章,指出蝙蝠身上的 SARS 冠状病毒原本不会感染人类,而石正丽团队人工制造出能感染人类的高危病毒,是人为制造出潜在的人类危机:

Engineered bat virus stirs debate over risky research

https://www.nature.com/news/engi ... ky-research-1.18787

在 2013 年,武汉病毒研究所 已经在 基因银行 注册了  AGZ48809.1 病毒,全称为 Bat SARS-like coronavirus RsSHC014。该病毒包膜与 武汉海鲜市场病毒 的包膜相似度达 94.74%:

wh.vir.a.png

而石正丽团队于 2015 年人工制造出来的能感染人类的病毒则名为 SHC014-MA15,这表明 武汉病毒研究所 对 SHC014 spike 的感染机制已经研究多年:

https://www.nature.com/articles/nm.3985



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 楼主| 发表于 2020-2-8 00:08:58 | 显示全部楼层
武汉肺炎病毒上,有「基因改造指纹」,证实该病毒为人造

Irrefutable: The coronavirus was engineered by scientists in a lab using well documented genetic engineering vectors that leave behind a “fingerprint”

https://yournews.com/2020/02/03/ ... cientists-in-a-lab/

在病毒研究学界,有一些基因修改工具和现成的基因序列,可以用来向病毒插入基因片段,或修改病毒的基因序列。

用这种方法修改过的病毒,会留下一些独特的痕迹,被称为「基因改造指纹」。

在武汉肺炎病毒上,发现了「基因改造指纹」,证明该病毒为人工改造而成。

Every virology lab in the world that has run a genomic analysis of the coronavirus now knows that the coronavirus was engineered by human scientists. The proof is in the virus itself: The tools for genetic insertion are still present as remnants in the genetic code. Since these unique gene sequences don’t occur by random chance, they’re proof that this virus was engineered by scientists in a lab.

......

China’s BSL-4 labs have experienced multiple accidental releases of SARS strains, and this new coronavirus is now confirmed to be an engineered strain that was either used in bioweapons research or vaccine experiments.

The genomic coding in the virus is not natural, in other words. Just as you would never encounter a snake in the desert that’s writing a book containing words and grammatical structure, the genetic sequences now identified in the coronavirus strain are, without question, proof that human engineers have been tinkering with the strain.

How to genetically engineer viruses: the pShuttle vector

One of the tools used to accomplish this genetic engineering is called pShuttle. It’s a genetic tool set that can carry a payload of genes to be inserted into the target virus.





......

During this process, of course, the pShuttle leaves behind unique code, a “fingerprint” of the genetic modification. It is this fingerprint that has now been identified in the coronavirus.

As revealed by genomics researcher James Lyons-Weiler in this bombshell analysis article, the pShuttle genetic code is found in the coronavirus that’s circulating in the wild.

This is proof that the virus has been engineered by human scientists.

“IPAK researchers found a sequence similarity between a pShuttle-SN recombination vector sequence and INS1378,” writes Lyons-Weiler for IPAK:



Another gene sequence also shows a 92% match with the Spike protein from the SARS coronavirus:



The process for achieving this was patented by Chinese researchers as shown in this patent link.

The pShuttle vector was used to insert SARS genes into the coronavirus, a process that makes it deadly to humans. “The very researchers conducting studies on SARS vaccines have cautioned repeatedly against human trials,” warns Lyons-Weiler:

The disease progression in of 2019-nCoV is consistent with those seen in animals and humans vaccinated against SARS and then challenged with re-infection. Thus, the hypothesis that 2019-nCoV is an experimental vaccine type must be seriously considered.

He concludes:

If the Chinese government has been conducting human trials against SARS. MERS, or other coronviruses using recombined viruses, they may have made their citizens far more susceptible to acute respiratory distress syndrome upon infection with 2019-nCoV coronavirus.

https://www.addgene.org/16402/

【Wikipedia】Shuttle vector
https://en.wikipedia.org/wiki/Shuttle_vector

【Wikipedia】Vector (molecular biology)
https://en.wikipedia.org/wiki/Vector_(molecular_biology)


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匿名
匿名  发表于 2020-2-9 02:08:12
来源:独评论坛
作者: cwing

http://duping.net/XHC/show.php?bbs=11&post=1424756

學術圈因爲有開放的傳統,誰有什麽藥是什麽思路大家都知道
控制病毒的辦法也就是那幾個,
實際上,生化研究的一大方法論就是做大量動物實驗,
讓大量實驗動物染病然後再給注射各種藥,先瞎貓碰死耗子看看那個有效,有效的再理論倒推,然後迭代下一輪實驗
武漢p4所5年的論文顯示就已經有和這次爆發病毒極爲相似的病毒了
也早就通過大量實驗知道針對埃博拉被淘汰出局的瑞得西韦卻對新冠有效,是該毒的解藥
怕誤傷美軍像伊朗那樣被斬首,江綿恆中科係看毒被放到美帝了就把解藥是哪個通報給了美方
沒想到川普又把這個配方轉囘給了包子

标题:江绵恒(中科院)之聲:印度假论文已撤稿!病毒绝非人工我用生命担保

作者: cwing

http://duping.net/XHC/show.php?bbs=11&post=1424697

江绵恒(中科院)之聲:印度假论文已撤稿,病毒非人工我用生命担保!
我蛤厲害啊,不叫通過同行評議就完了唄
居然施壓叫印度自己撤稿了

标题:中科系惯用毒不止汉病毒所,京高能所诉江,中科院精准毒杀满院法轮

http://duping.net/XHC/show.php?bbs=11&post=1424711

不止中科院武汉P4病毒所
江儿子的中科院系统似乎惯于用毒,而且用的隐蔽精准,可谓朝中第一用毒高手
比政法系tg的用毒手法要高明的多,
政法系多是学渣念警校,只会摁住强灌针头死扎,糙得很
中科系多为学霸出身,把毒用得,真叫个润物细无声
念过书的就是不一样
呵呵
江绵恒(中科院)之聲拍着胸脯“用生命担保 ”说病毒绝非人工
我看,从反面说明,人工病毒这事算是实锤了


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 楼主| 发表于 7 天前 | 显示全部楼层
武汉肺炎病毒被国际正式认定为 SARS 姐妹病毒

国际病毒分类委员会( International Committee on Taxonomy of Viruses)正式宣布,把暂称 2019-nCoV 的新型冠状病毒,正式命名为 SARS-CoV-2(severe acute respiratory syndrome coronavirus 2,即 SARS冠状病毒2),并认定为 SARS冠状病毒(SARS-CoV)的姐妹病毒。

The W.H.O. announced on Feb. 11 a new name for the disease caused by the current novel coronavirus epidemic: Corona Virus Disease (COVID-19). As for the virus itself, the International Committee on Taxonomy of Viruses has decided on SARS-CoV-2, which “formally recognizes this virus as a sister to severe acute respiratory syndrome coronaviruses.”

https://globalbiodefense.com/novel-coronavirus-covid-19-portal/


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匿名
匿名  发表于 5 天前

完整的武汉海鲜市场病毒(正式名称为 SARS-CoV-2 病毒,即武汉肺炎病毒),已在基因银行注册:

https://www.ncbi.nlm.nih.gov/nuccore/MN908947.3
Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome
GenBank: MN908947.3

SOURCE       Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
ORGANISM  Severe acute respiratory syndrome coronavirus 2

运行 BLAST 进行基因比对,发现 武汉肺炎病毒南京军区军事医学研究所 于 2018 年提交的 MG772933.1 和 MG772934.1 病毒 相似度分别达到 89.12% 和 88.65%。

另有一相似度达 82.30% 的 KY417146.1 病毒,由 武汉病毒研究所 于 2016 年提交。

wuhan.vir.compl.blast.png

以上资料证明,解放军 和 武汉病毒研究所 对类似病毒早已研究多年。


南京军区军事医学研究所 于 2018 年提交的 MG772933.1 病毒:

https://www.ncbi.nlm.nih.gov/nucleotide/MG772933.1
Bat SARS-like coronavirus isolate bat-SL-CoVZC45, complete genome
GenBank: MG772933.1

SOURCE       Bat SARS-like coronavirus
ORGANISM  Bat SARS-like coronavirus

Submitted (05-JAN-2018) Institute of Military Medicine Nanjing Command, Nanjing,
Institute of Military Medicine Nanjing Command, Nanjing, NO. 293 East Zhongshan Road, Nanjing, JangSu 210002, China


南京军区军事医学研究所 于 2018 年提交的 MG772934.1 病毒:

https://www.ncbi.nlm.nih.gov/nucleotide/MG772934.1
Bat SARS-like coronavirus isolate bat-SL-CoVZXC21, complete genome
GenBank: MG772934.1

SOURCE       Bat SARS-like coronavirus
ORGANISM  Bat SARS-like coronavirus

Submitted (05-JAN-2018) Institute of Military Medicine Nanjing Command, Nanjing,
Institute of Military Medicine Nanjing Command, Nanjing, NO. 293 East Zhongshan Road, Nanjing, JangSu 210002, China


武汉病毒研究所 于 2016 年提交的 KY417146.1 病毒:

https://www.ncbi.nlm.nih.gov/nucleotide/KY417146.1
Bat SARS-like coronavirus isolate Rs4231, complete genome
GenBank: KY417146.1

SOURCE      Bat SARS-like coronavirus
RGANISM   Bat SARS-like coronavirus

Submitted (30-DEC-2016) CAS Key Laboratory of Special Pathogens and Biosafety and Center for Emerging Infectious Diseases,
Wuhan Institute of Virology, Chinese Academy of Sciences, No. 44 Xiao Hong Shan, Wuhan, Hubei 430071, China


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匿名
匿名  发表于 4 天前
生物科学家 James Lyons-Weiler 认为 武汉肺炎病毒 是人工制造的


https://www.youtube.com/watch?v=DwpAY2EPVFk


https://www.youtube.com/watch?v=g1tZ8Xwf9r8

On the Origins of the 2019-nCoV Virus, Wuhan, China
https://jameslyonsweiler.com/202 ... -virus-wuhan-china/


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 楼主| 发表于 3 天前 | 显示全部楼层
本帖最后由 observer16 于 2020-2-17 11:36 编辑


多个研究机构联名论文证实,类似武汉肺炎病毒的人造病毒,以前已经被成功制造过出来

由 南开大学数学科学学院、南开大学生命科学学院、齐鲁师范学院生命科学学院、东部战区总医院、昆明医科大学分子临床医学研究院 联合发表的论文《武汉2019冠状病毒S蛋白可能存在Furin蛋白酶切位点》:

http://www.chinaxiv.org/abs/202002.00004v3

摘要:

2019年12月,中国武汉报道了2019新型冠状病毒(2019 novel Coronavirus,2019-nCoV)引起的肺炎。基于基因组信息,我们前期研究结果显示2019-nCoV与SARS冠状病毒虽然同属于Beta冠状病毒B亚群(BB冠状病毒),但两种病毒差异很大,这一结果与两者临床症状差异一致。前期研究还发现了BB冠状病毒存在大量的可变翻译,并从分子水平揭示了BB冠状病毒变异快、多样性高的特点。本研究在国际上首次报道BB冠状病毒S蛋白上的一个重要突变,这个突变使2019-nCoV具有了一个可供Furin蛋白酶切的位点,是除鼠肝炎冠状病毒外所有的其它BB冠状病毒(包括SARS和SARS样(SARS-like)冠状病毒)所不具有的。这个突变有可能增强了2019-nCoV侵染细胞的效率,进而使其传播力显著大于SARS冠状病毒。由于这个突变,2019冠状病毒的包装机制也会不同于SARS等其它大部分Beta冠状病毒,而有可能与鼠肝炎冠状病毒、HIV、埃博拉病毒和一些禽流感病毒的包装机制相同。

wh.vir.Furin.png

该文引发的思考:

武汉肺炎病毒(2019-nCoV,正式名称为 SARS-CoV-2)虽是 SARS 的同类病毒,却具有一个与 SARS 病毒格格不入的重要变异(2019-nCoV 具有一个可供 Furin 蛋白酶切的位点),使得武汉肺炎病毒的包装机制不同于 SARS 病毒,而变成与 鼠肝炎、HIV、Ebola 等病毒的包装机制相同。

那么,一个病毒里的一小部分发生精确突变,变成另一类病毒的包装机制,这可能是自然发生的吗?机率有多大?这种情况,是不是更像人工剪接、合成的呢?

而且论文中提到,在 SARS 病毒里 人为加入 Furin 酶切位点,在以前的实验里已经做到过。也就是说,人工制造武汉肺炎病毒,技术上是完全可以做到的,而且以前早就人工制造过类似的病毒。

该论文似乎还暗示,禽流感病毒也可能是人工制造出来的。
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匿名
匿名  发表于 昨天 10:30
来源:独评论坛
作者:cwing

http://duping.net/XHC/show.php?bbs=11&post=1425009

tg内部通報,病毒已經變異,無法治愈,有後遺症
已經證實痊愈的又復發,轉陰的還帶毒,能繼續傳染,
内部防控錄音,很大一部分到死不發熱,無法控制
病毒變異已經變得之前的核酸準確率從6成降到4成到現在兩成
治療重症的特效藥還沒量產,衹能用來治療輕症了
這病就不會消失了,以後估計每年冬春來一次


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